Last update:   January 5, 2011
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Reviews and fundamental papers
Other information
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Basic Methods in Protein Purification and Analysis: A Laboratory Manual
Richard J. Simpson, Peter D. Adams and Erica A. Golemis
436 pp., Cold Spring Harbor Laboratory Press, 1 edition, November 2008
ISBN: 978-0879698676 [Amazon]

Biocalorimetry2: Applications of Calorimetry in the Biological Sciences
John E. Ladbury and Michael L. Doyle
276 pp., Wiley, August 2004
ISBN: 978-0470849682 [Amazon]

Marja Makarow and Ineke Braakman
299 pp., Springer, April 2006
ISBN: 978-3540325802 [Amazon]

Fundamentals of Protein Structure and Function
Engelbert Buxbaum
367 pp., Springer, September 2007
ISBN: 978-0387263526 [Amazon]

Mass Spectrometry Analysis for Protein-Protein Interactions and Dynamics
Mark Chance
288 pp., Wiley, September 2008
ISBN: 978-0470258866 [Amazon]

Mass Spectrometry of Protein Interactions (Wiley - Interscience Series on Mass Spectrometry)
Kevin Downard
137 pp., Wiley-Interscience, August 2007
ISBN: 978-0471793731 [Amazon]

Principles of Proteomics (Advanced Text Series)
Richard Twyman
266 pp., Taylor & Francis, September 2004
ISBN: 978-1859962732 [Amazon]

Protein Folding Kinetics : Biophysical Methods
Bengt Nölting
222 pp., Springer, September 2005
ISBN: 978-3540272779 [Amazon]

Protein Interaction Networks: Computational Analysis
Aidong Zhang
292 pp., Cambridge University Press, April 2009
ISBN: 978-0521888950 [Amazon]

Protein Interactions: Biophysical Approaches for the Study of Complex Reversible Systems (Protein Reviews)
Peter Schuck
532 pp., Springer, April 2007
ISBN: 978-0-387-35965-6 [Amazon]

Protein Microarray Technology
Dev Kambhampati
276 pp., Wiley-VCH, March 2004
ISBN: 978-3527305971 [Amazon]

Protein-Protein Interaction
M. Werther, H. Seitz and T. Scheper
288 pp., Springer Berlin Heidelberg, December 2009
ISBN: 978-3642088384 [Amazon]

Protein-Protein Interactions: A Molecular Cloning Manual
Erica Golemis
682 pp., Cold Spring Harbor Laboratory Press, December 2001
ISBN: 978-0879696283 [Amazon]

Protein-Protein Interactions: A Molecular Cloning Manual
Erica Golemis and Peter D. Adams
938 pp., Cold Spring Harbor Laboratory Press, 2nd edition, October 2005
ISBN: 978-0879697235 [Amazon]

Protein-protein Interactions and Networks: Identification, Computer Analysis, and Prediction (Computational Biology)
Anna Panchenko and Teresa Przytycka
212 pp., Springer, August 2008
ISBN: 978-1848001244 [Amazon]

Protein-Protein Interactions: Methods and Applications
Methods in Molecular Biology, Clifton, N.J., Vol. 261
Haian Fu
544 pp., Humana Press, March 2004
ISBN: 978-1588291202 [Amazon]

Protein-Protein Interactions in Plant Biology
Michael T. McManus, William A. Laing and Andrew C. Allan
325 pp., Blackwell, January 2002
ISBN: 978-0849397905 [Amazon]

Protein Structure, Stability, and Interactions (Methods in Molecular Biology)
John W. Shriver
362 pp., Humana Press, 1 edition, October 2008
ISBN: 978-1588299543 [Amazon]

Timothy Palzkill
127 pp., Springer, January 2002
ISBN: 978-0792375654 [Amazon]

Proteomics and Protein-Protein Interactions : Biology, Chemistry, Bioinformatics, and Drug Design (Protein Reviews)
Gabriel Waksman
324 pp., Springer, December 2005
ISBN: 978-0387245317 [Amazon]

Proteomics in Drug Research
Michael Hamacher, Katrin Marcus, Kai Stühler, Andre van Hall, Bettina Warscheid and Helmut E. Meyer
383 pp., Wiley-VCH, May 2006
ISBN: 978-3527312269 [Amazon]

The Yeast Two-Hybrid System
Paul L. Bartel and Stanley Fields
360 pp., Oxford University Press, October 1997
ISBN: 978-0195109382 [Amazon]

Two-Hybrid Systems: Methods and Protocols (Methods in Molecular Biology, Vol. 177)
Paul N. MacDonald
352 pp., Humana Press, June 2001
ISBN: 978-0896038325 [Amazon]

Yeast Hybrid Technologies
Li Zhu and Gregory J. Hannon
396 pp., Biotechniques Eaton Pub., December 2000
ISBN: 1881299155 [Amazon]

Reviews and fundamental papers
Aebersold, R.; Mann, M.; Nature 2003, 422(6928), 198-207. Mass spectrometry-based proteomics.
Bacart, J.; Corbel, C.; Jockers, R.; Bach, S.; Couturier, C.; Biotechnol. J. 2008, 3(3), 311-324. The BRET technology and its application to screening assays.  
Brückner, A.; Polge, C.; Lentze, N.; Auerbach, D.; Schlattner, U.; Int. J. Mol. Sci. 2009, 10(6), 2763-2788. Yeast two-hybrid, a powerful tool for systems biology.  
Ehlert, A.; Weltmeier, F.; Wang, X.; Mayer, C.S.; Smeekens, S.; Vicente-Carbajosa, J.; Droge-Laser, W.; Plant J. 2006, 46(5), 890-900. Two-hybrid protein-protein interaction analysis in Arabidopsis protoplasts: establishment of a heterodimerization map of group C and group S bZIP transcription factors.  
Fields, S.; Sternglanz, R.; Trends Genet. 1994, 10(8), 286-292. The two-hybrid system: an assay for protein-protein interactions.  
Matsuzawa, S.; Reed, J.C.; Methods Mol Biol. 2007, 383, 215-225. Yeast and mammalian two-hybrid systems for studying protein-protein interactions.  
Phizicky, E.M.; Fields, S.; Microbiol. Rev. 1995, 59(1), 94-123. Protein-protein interactions: methods for detection and analysis.
Piehler, J.; Curr. Opin. Struct. Biol. 2005, 15(1), 4-14. New methodologies for measuring protein interactions in vivo and in vitro.
Ratushny, V.; Golemis, E.; Biotechniques 2008, 44(5), 655-662. Resolving the network of cell signaling pathways using the evolving yeast two-hybrid system.  
Uetz, P.; Curr. Opin. Chem. Biol. 2002, 6(1), 57-62. Two-hybrid arrays.
Uetz, P.; Hughes, R.E.; Curr. Opin. Microbiol. 2000, 3, 303-308. Systematic and large-scale two-hybrid screens.
Van Criekinge, W.; Beyaert, R.; Biological Procedures Online 1999, 2(1), 1-38. Yeast two-hybrid: state of the art.
Vidal, M.; Legrain, P.; Nucleic Acids Res. 1999, 27(4), 919-929. Yeast forward and reverse 'n'-hybrid systems.
Vollert, C.S.; Uetz, P.; Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine, Springer Verlag, 2003, The two-hybrid System.
Walhout, A.J.; Vidal, M.; Methods 2001, 24, 297-306. High-throughput yeast two-hybrid assays for large-scale protein interaction mapping.  

Other information
AlphaScreen® (Perkin Elmer, Inc.)
  • Amplified Luminescent Proximity Homogeneous Assay (ALPHA)
  • very sensitive non-radioactive homogeneous assay technology that allows the screening of a large range of biological interactions and activities
BacterioMatch™ (Agilent Technologies)
  • two-hybrid system
  • alternative or complement to yeast two-hybrid systems for in vivo detection of protein-protein interactions [PDF]
Biacore Life Sciences (Biacore)
CheckMate™ (Promega GmbH)
  • mammalian two-hybrid system [PDF]
CytoTrap® (Agilent Technologies)
  • two-hybrid system [PDF]
Custom Yeast Two-hybrid Screening Services (Creative Biolabs™)
DUAL Hybrid System (Dualsystems Biotech AG)
  • data sheet [PDF]
Fluorescence Correlation Spectroscopy (FCSXpert™ Solutions)
Interaction Analysis by High-Mass MALDI (COVALX)
Matchmaker (Clontech)
  • data sheet [PDF]
PepSpots™ (JPT Peptide Technologies GmbH)
  • peptide arrays for mapping protein interactions
Pierce Protein Interaction Mapping Kit (Thermo Fisher Scientific Inc.)
Protein-Protein Interaction Studies (Biocompare)
Proteomics / Protein - Protein Interactions / Experimental (WikiBooks)
ProtoArray® (Invitrogen GmbH)
RayBio® Protein Array (RayBiotech Inc.)


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